Overreliance on a few main crops, as well as poor soil health, reduce yields, hinder achievement of food security and nutrition objectives, and increase agricultural vulnerability to climate change. To address this, the Vision for Adapted Crops and Soils (VACS), launched by the United States in partnership with FAO and the African Union, and as part of the whole-of-government Feed the Future initiative, seeks to support soil health as well as breeding of traditional and indigenous crops in Africa. Building on U.S. government food security efforts, VACS’ goal is to accelerate development of improved crop varieties that could lead to increases in both yield and nutrition, to tackle the challenges of food insecurity in the context of climate change.